In this lesson, students explore the concept of genetics and inheritance. The lesson focuses on sickle cell anemia, a genetic disease that is dependent on a recessive trait. Students will perform data collection and analysis of the probability of a child of two sickle trait parents inheriting sickle cell anemia. To do this, they play a game that models how the inheritance of a disease works from parents’ genes. Later, students construct family trees with probability to determine the genotypes of family members.